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Research on Hemophilia Essay Sample. The word Hemophilia is derived from two Greek words haima, blood, and philein, to love and, despite being senseless in the description of excess bleeding, it remains in general use. In the older literature various names have been used, e.g. Poster Examples? hemorraphilia, hematophilia, hemorrhea, hemorrhagophilia, idiosyncrasia haemarrhagica and morbus haematicus. This first use of the world hemophilia is attributed to Schonlein, who gave a dissertation entitled Die Hamophiliet at Wurzburg in 1828. The disease is now called haemophilia A or classic haemophilia and is due to deficient activity of antihemophilic factor (AHF, antihemophilic globulin (AHG) or factor VIII. A variety has been described which is how to, called Christmas disease in the UK but in Europe and the USA is dissertation poster examples, often called haemophilia B or plasma thromboplastin component (PTC) deficiency.

This is due to deficient activity of Christmas factor (CF, PTC or factor IX). The clinical manifestations of these two diseases are essentially similar and no differentiation is of factors of production, made between them with regard to bleeding tendency. Dissertation? It is probable that genetically determined bleeding disorders are as old as time but they seem to have been neglected by Essay, the Egyptian, Romans and Greek physicians. The earliest documented case of a familial bleeding disorder occurs in the fourth-century Talmud and in dissertation examples, Rabbinic writings thereafter. Perhaps the most famous hemophilic family internationally is that of Queen Victoria, who in 1853 gave birth to her eighth child, Leopold, Duke of be a cashier, Albany, and he was a haemophiliac. Dissertation Poster Examples? In addition to this, two of her daughters proved to be carriers. It can truly be said that the result of the transmission of haemophilia into the royal families of Europe had a profound effect on the mighty, the course of European history.

Nowhere is dissertation poster, this more poignant than in the case of Alexandra, who became the freak consort of Tsar Nicholas the poster Second of Empires, Russia, who produced Alexis, a severely affected haemophiliac, in 1904. In Victorias family there was no evidence of any ancestor with hemophilia and it must be presumed that the disease was due to mutant gene. The proponent aims to: 1. compare and contrast the differences of hemophilia A and hemophilia B. 2. Dissertation Examples? explain how hemophilia is diagnosed. 3. explain the complications that may arise if hemophilia is Essay, not diagnosed early. The proponent endeavors to provide answers to the following: 1. What are differences between hemophilia A and hemophilia B? 2. Dissertation Poster Examples? How is hemophilia diagnosed? 3. What are the complications that may arise if hemophilia is not diagnosed early? A comparison and contrast pattern arranges information according to how two or more things are similar to good, or different from one another (or both).

This is an effective pattern to use when the reader can better understand one subject when it is described in relation to another. If the reader is familiar with one topic, the writer can compare or contrast it with another topic to shed insight on it. The proponent will be using compare and contrast for the topic Hemophilia by dissertation poster, comparing Hemophilia A and Hemophilia B. This principle of organization will present the freak the mighty review similarities and differences between these two types of hemophilia which are clinically almost identical. Poster Examples? The proponent thinks that Comparison and Contrast would be an effective way for developing this paper about the topic Hemophilia. Factor VIII only affect men Factor IX. Deficiency Deficiency have a genetic mutation on the X chromosome 1 in 5,000 1 in 30,000. Males affects all people of how to good, all Males races and ethnics. Both types of hemophilia is caused by the lack of clotting factor in the blood which makes them bleed internally, mainly into muscles and joints Both types of hemophilia is caused by dissertation poster examples, the lack of clotting factor in the blood which makes them bleed internally, mainly into muscles and joints globally. Hemophilia is a rare disease wherein it slows down the what connection between president fourteen points and germany’s process of blood clotting. If you have hemophilia, you may bleed for a longer time than others after an dissertation, injury.

It has its two major forms Hemophilia A and Hemophilia B. The Mighty? Both have several similarities and differences as well as its various characteristics as of some of which seen in the framework above. Both are diagnosed in the same way except only that they have different factors which they lack in the blood in dissertation poster examples, order for it to over, have a normal blood clotting process. This disease is dissertation, already known and does have remedies and diagnoses. But one thing I can say, we do not yet what effects does this kind of disease bring about if a person with hemophilia is not diagnosed at wilson’s points surrender?, an early time as this disease is very critical for it does not have any permanent or stable treatment at this moment in poster examples, time with the Empires given present level of dissertation poster, technology. We will be able to know it as this paper is enriched with further researches and studies with the help of the principle of organization comparison and contrast. The word Hemophilia is derived from two Greek words haima, blood, and philein, to review, love and, despite being senseless in the description of excess bleeding, it remains in poster examples, general use. Hemophilia is the term given to a bleeding disorder wherein the person experiences bleeding spontaneously or following after an injury (Forbes, 1997, 3).

Nature of Hemophilia. Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B. Low levels or complete absence of a blood protein essential for clotting causes this disorder. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. Approximately 85% have hemophilia A and the remainder has hemophilia B. The severity of hemophilia is related to the amount of the clotting factor in Empires, the blood. About 70% of hemophilia patients have less than one percent of the normal amount and, thus, have severe hemophilia. A small increase in the blood level of the clotting factor, up to poster examples, five percent of normal, results in connection between fourteen surrender?, mild hemophilia with rare bleeding except after injuries or surgery (Kemball-Cook, 1997,21). How Hemophilia is poster examples, inherited. Hemophilia types A and B are inherited diseases passed on from a gene located on the X chromosome; therefore it is a sex-linked disease.

About 70% of all individuals with hemophilia A or B inherited the disease. The other 30% have hemophilia because of a spontaneous genetic mutation. Females have two X chromosomes, while males have one X and one Y chromosome. A female carrier of hemophilia has the hemophilia gene on one of her X chromosomes, and there is a 50 percent chance that she may pass the defective gene to her male offspring. Males who inherit the defective gene will develop hemophilia. Males with hemophilia do not pass the gene to their sons; however, they do pass the gene to their daughters. Females who inherit the defective gene will become carriers who may, in turn, have a 50 percent chance of passing it on to their children. Although females who inherit the gene generally have no active problems related to hemophilia, some may have other problems associated with bleeding, such as excessive menstrual bleeding, frequent or severe nosebleeds, or bleeding after dental procedures or surgery. In about one-third of hemophilia cases, there is no family history of the disease.

These cases are due to a new or spontaneous development of the defective gene in the female. In the rare event of a hemophiliac father and Cold Mountain a carrier mother, the right combination of parental chromosomes will result in a hemophiliac female child. This situation, however, is extraordinarily rare. The vast majority of individuals with either hemophilia A or B, then, are male. As mentioned earlier, about 30% of all individuals with hemophilia A or B are the first members of their families to ever present with the disease. These individuals had the unfortunate occurrence of a spontaneous genetic mutation, meaning that early in dissertation, development, some random genetic accident befell their X chromosome, resulting in the defect causing hemophilia A or B (Yhe, 1997, 229). Why Hemophiliacs Bleed. The ability to stem blood loss after vascular injury is vital for all vertebrate species. Essentially simultaneously, escape of blood through the over my life gap created by minimal vascular damage is normally staunched by platelets, a nuclear cells that arise from the break-up of the dissertation examples of the cytoplasm of megakaryocytes, a process stimulated by freak the mighty, a trace plasma polypeptide, thrombopoeitin, that promotes both the proliferation and differentiation of poster examples, megakaryocyte progenitor cells. The platelets form a mechanical plug that can seal minor breaches in the vascular wall. Platelets do this by connection between wilson’s fourteen points surrender?, sticking to the edges of severed vessels, to exposed sub endothelial structures such as collagen, and to each other.

Adhesion of platelets to these structures is enhanced by plasma von Willebrand factor, a protein deficient in von Willebrands disease that reacts with a specific receptor on platelet membranes, glycoprotein. Contact of platelets with the collagen induces activation of poster, these cells which release biologically active agents from The Three Empires, their cytoplasmic granules that enhance the formation of platelet aggregates. The bridges between the aggregated platelets are composed of fibrinogen molecules that bind to specific glycoprotein receptors, GPIIb/IIIa, on the platelet surfaces. The adherent and aggregated platelets clump rapidly, forming a hemostatic plug that can close small gaps in the walls of blood vessels. Platelet aggregation is brought about by a cyclic endoperoxide, thromboxane A2, a derivative of arachidonic acid that is dissertation poster, released from the of production platelet membrane phospholipids when these cells have been stimulated by collagen, adenosine diphosphate (ADP) or other agonists. Essentially simultaneously, gaps in examples, the vascular wall are closed by generation of a blood clot, that is, by over my life, transformation of liquid blood to a gel-like coagulum, which consolidates the platelet aggregates.

Contributing to the generation of a clot when platelets become activated are changes in the platelet surface that make procoagulant phospholipoproteins available. Coagulation of blood at the site of examples, injury can diminish or halt blood loss from vascular defects larger than those that can be controlled by platelets alone. When bleeding occurs into a closed space such as the tip of a finger or toe, blood loss is minimized by the back-pressure of was the between president points, extravastated blood; the important of this device can be appreciated by the extensive loss of blood that may occur in otherwise normal individuals after injury to dissertation examples, periorbital tissues or to an intraperitoneal vessel. In these situations, the accumulated shed blood usually does not provide sufficient back-pressure to stop blood flow. Freak The Mighty? Extravascular pressure may also be important in limiting bleeding within joint spaces. In the special case of the uterus, bleeding after delivery is further controlled by contraction of the myometrium, applying external pressure on dissertation poster, blood vessels at the site of the Empires avulsed placenta. Dissertation? A similar mechanism may participate in the control of menstrual bleeding. The importance of blood coagulation for the control of freak the mighty review, bleeding is readily understood from the hemorrhagic tendency of individuals with hereditary clotting defects. Clotting is the poster examples end-result of a series of The Three, chemical events that are initiated upon contact of blood with either injured tissue or with negatively charged surfaces such as glass. Perturbation of blood in these ways starts sequential reaction that result, in poster examples, the end, in the release of a plasma protease, thrombin that brings about coagulation.

At each step, a plasma protein clotting factor undergoes limited proteolysis that results in its conversion to a form with enzymatic activity until, in the end; prothrombin is cleaved proteolytically, releasing enzymatically active thrombin. A characteristic of these clotting factors is that they may have multiple functions, suggesting that their role has been determined by the forces of freak the mighty review, evolution (Ratnoff, 1997, 7). Dissertation Poster Examples? Factor VIII. The hemostatic system, consisting of the back my life blood vessels and their content, blood, plays a crucial role in human survival. The importance of the plasma coagulation system in protecting life by dissertation poster, preventing further blood loss following transection of a blood vessel is Essay, well recognized. Blood is usually maintained in a fluid state, without evidence of dissertation examples, bleeding or clotting. The presence of an X-linked pattern of inheritance of a bleeding diathesis in families, referred to as hemophilia, has been recognized for looking back, hundreds of years.

That hemophilia is due to a deficiency of a factor (F) in the blood was proven in 1840 by correction of the bleeding defect with transfusion of whole blood; this was followed in 1911 by the demonstration that normal plasma could shorten the whole blood clotting time of hemophilic blood. Dissertation Examples? Then, in 1937, a factor from normal plasma was shown to be effective in accelerating the coagulation of hemophilic blood, and of factors the term antihemophilic globulin was coined; this protein is poster examples, now referred to as factor VIII-C (FVIII-C). Further progress was achieved in the 1950s with the development of cryoprecipitate and plasma concentrates to treat hemophilia A (FVIII deficiency). The Three Essay? The clinical and therapeutic observation that clotting time was corrected after transfusion of blood from one hemophilic patient to another was followed by the description of plasma thromboplastin component or factor IX deficiency. This second type of dissertation, deficiency was referred to as hemophilia B to differentiate it from hemophilia A. Clarification of the structure and function of the factor VIII molecule (FVIII-C, an X-linked gene product, also known as antihemophilic globulin) noncovalently bound to von Willebrand factor (vWF, an autosomal 12p gene product) in plasma clarified the separate roles of factor VIII-C (antihemophilic globulin) and von Willebrand factor proteins.

This led to an understanding of the role of the different components of the factor VIII molecule in the physiology of normal hemostasis and to a recognition that hemophilia A and examples of factors von Willebrand disease were caused by a deficiency of different proteins in dissertation examples, the factor VIII complex. An understanding of the Essay on Mountain reasons for the development of factor VIII inhibitors in persons with hemophilia or in persons with previously normal hemostasis (referred to as acquired hemophilia) expanded understanding of the antigenic structure of the dissertation poster examples factor VIII molecule. Cloning of the factor VIII gene was followed by the preparation of recombinantly derived factor VIII (rFVIII) as replacement therapy for the missing factor. Between President Wilson’s Points And Germany’s? Several different vectors have now been used to correct factor VIII deficiency in poster examples, humans, with many questions still to be a good, be resolved. Poster? The potential role of increased levels of factor VIII in thrombophilic states continues to freak review, be explored. Primary immunodeficiency diseases (PIDs) are associated with various autoimmune complications and several manifestations of autoimmunity. Acquired hemophilia is rare in dissertation poster, childhood even though autoantibodies may develop in various forms of primary immunodeficiency diseases. However, acquired hemophilia may rarely form factor VIII inhibitors in patients with undefined primary immunodeficiency disease features that are suggestive of autosomal recessive hyper-immunoglobulin (Ig) E syndrome (Berntorp, 1997, 181). The most significant breakthroughs in comprehending the mechanisms associated with coagulation first came from an understanding of the individual causes of the Essay on Cold Mountain bleeding disorders. The recognition in 1952 that hemophilia B was due to a deficiency of a coagulation factor followed the discovery that hemophilia A was caused by the deficiency of dissertation poster examples, another clotting factor. Also termed Christmas disease, hemophilia B is an X-linked inherited bleeding disorder, usually manifested in males and transmitted by females when they carry the abnormality on examples of factors, the X chromosome.

Hemophilia B is caused by a deficiency or dysfunction of factor IX (FIX) resulting from a variety of defects in the FIX gene. FIX deficiency is 4-6 times less prevalent than factor VIII (FVIII) deficiency. The newspaper item below demonstrates what appears to be a late 19th-century record of dissertation poster, hemophilia passed from mother to sons. Mutations in human coagulation factor IX that cause hemophilia B may be classified as severe, moderately severe and mild based on the plasma levels of factor IX among affected individuals ( 1%, 2-5%, 6-30%, respectively). Recently, hemophilia B was shown to be a disease with mutations showing clinical variation (Lusher, 1997, 203). Diagnosis of Hemophilia A and B Carriers. Hemophilia A and B are X-linked diseases where precise carrier detection and prenatal diagnosis are increasingly an integral part of care of the what connection between president wilson’s fourteen points and germany’s patient and family. Dissertation Poster Examples? Carrier assessment can be made in several ways: 1. Clinical diagnosis based on an individuals bleeding history in a family where haemophilia has been diagnosed. 2. Diagnosis within a family with haemophilia based upon a detailed family tree where no uncertainties (e.g. Empires? questions of dissertation poster examples, paternity) are present. 3. Diagnosis based on reduced levels of plasma factor VIII (FVIII) or factor IX (FIX).

4. Of Factors? Genetic diagnosis by analysis of the FVIII or FIX genes within families either by polymorphism-based gene tracking (linkage analysis) or mutation detection (Goodeve, 1997, 63). Clinical and phenotypic diagnosis of carrier status. Female carriers of dissertation poster examples, haemophilia A or B have generally inherited their abnormal FVIII or FIX gene from one of their parents, together with a normal gene. Thus, on average, carriers of severe disease, where affected males have very low or undetectable levels of FVIII or FIX, will have a plasma levels around 50% of normal. Carriers of milder conditions will tend to have levels greater than 50%, since the defective gene will be able to what was the president fourteen and germany’s, produce some clotting factor. Bleeding symptoms may be present in carriers if their plasma factor level is below 40%. This generally occurs as a result of extreme lyonization, although other rare possibilities, including homozygosity, Turners syndrome and co-inheritance of von Willebrands disease should be considered.

The starting point for any family study in haemophilia must be an accurate family tree, showing the precise relationship between affected and non-affected family members. The nature of the inherited condition (haemophilia A or B) must be certain and the ethnic background of the family may also be important. With good family data it may be immediately possible to exclude or include carrier status in poster examples, certain females. Thus, carriership can be excluded for a female if haemophilia only occurs in her paternal family and freak the mighty her father has haemophilia or she has more than one hemophilic son or she has one affected son and her family includes a well-documented haemophiliac on her maternal side. The remaining females within a hemophilic family should be considered to be possible carriers, particularly on families where the dissertation individual concerned has one hemophilic son and no family history of the disease (isolated cases). The assignment to on Cold, a possible carrier of a probability of carriership is the essence of dissertation poster examples, carrier detection and is only examples of factors of production absolute when the precise genetic defect within the FVIII or FIX gene has been identifies within her family and herself. Conversely, the absence of the dissertation poster mutation confers to the status of non-carrier. However, the procedures necessary for such diagnoses are unavailable to the majority of the worlds hemophilic families at present and phenotypic methods are still widely used in carrier analysis.

The assessment of carrier status based on a family tree is calculated using anterior and descendent pedigree information to freak the mighty, calculate an overall probability or odds of carriership of 1.0 (obligate carrier), and dissertation examples her daughters a probability of 0.5. Her granddaughters will have a probability of 0.25 (0.5?0.5) (Goodeve, 1997, 64). Complications that may arise from the treatment. Deep internal bleeding Hemophilia may cause deep muscle bleeding that leads to was the fourteen points and germany’s surrender?, swelling of a limb. The swelling may press on nerves and lead to numbness or pain. Dissertation Poster? This may result in examples, a reluctance to dissertation poster, use that limb. Damage to joints Internal bleeding may also put pressure on and damage joints. Pain sometimes may be severe, and you may be reluctant to use a limb or move a joint.

If bleeding occurs frequently and you dont receive adequate treatment, the irritation may lead to between fourteen points and germany’s, destruction of the poster joint or the development of arthritis. Infection People with hemophilia are more likely to receive blood transfusions and are at greater risk of receiving contaminated blood products. Until the mid-1980s, it was more likely for people with hemophilia to what between wilson’s, become infected with the human immunodeficiency virus (HIV) or with hepatitis through contaminated blood products. Since then, blood products are much safer because of steps taken to screen the supply of donated blood. The risk of infection through blood products also has decreased substantially since the introduction of dissertation poster examples, genetically engineered clotting products called recombinant factors, which are free of infection. How To Be A Good? However, its still possible for people who rely on dissertation poster examples, blood products to contract diseases.

If you have hemophilia, consider receiving immunization against hepatitis A and how to be a B. Adverse reaction to clotting factor treatment In some people with hemophilia, the immune system sees these clotting factor treatments as foreign. When this happens, the dissertation examples immune system develops proteins that inactivate the clotting factors used to treat bleeding. How To Be A Good? Researchers are investigating treatments to dampen the immune systems response and allow continuing treatment with clotting factors (Rickard, 1997, 53). Proposition 1: Hemophilia is the oldest known hereditary bleeding disorder. Dissertation Examples? The earliest documented case if hemophilia occurs in the fourth century Talmud and in Rabbanic writings thereafter. This bleeding disorder is as old as time but they seem to have been neglected by the Egyiptian, Roman, and Greek physicians (Kemball-Cook, 1997, 21). Proposition 2: Patients with hemophilia A lack the blood clotting protein. Favtor VIII.

Hemophilia A is the most common type of hemophilia. The Mighty Review? It is also known as factor VIII deficiency or classic hemophilia. Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is examples, encoded by the F8 gene. Defects in this gene results in hemophilia A, a well-known recessive X-linked coagulation disorder (Kemball-Cook, 1997, 21). Proposition 3: Patients with hemophilia B lack the blood clotting protein. Essay Cold? Favtor IX. Hemophilia B is the poster examples second most common type of hemophilia.

It can also be known as factor IX deficiency, or Christmas disease. The Mighty Review? Factor IX is produced as a zymogen, an inactive precursor. It is processed to remove the examples signal peptide, glycosylated and then cleaved by good, factor XIa (of the poster contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulphide bridge (Kemball-Cook, 1997, 21). Proposition 4: The severity of hemophilia is related to the amount of the clotting factor in the blood. About 70% of hemophilia patients have less than one percent of the normal amount, and, thus, have severe hemophilia. A small increase in Essay Mountain, the blood level of the clotting factor, up to five percent of normal, results in poster, mild hemophilia with rare bleeding except after injuries or surgery (Yhe, 1997, 229). Proposition 5: Hemophilia is a sex-linked disease. Factor VIII and factor IX are located on the long arm of the X chromosome.

Females have two X chromosomes, while males have one X and one Y chromosome. A female carrier of Essay Cold Mountain, hemophilia has the dissertation hemophilia gene on one of here X chromosomes, and on Mountain there is dissertation poster, a 50 percent chance that she may pass the defective gene to freak the mighty review, her male offspring (Yhe, 1997, 229). Proposition 6: Males who inherit the defective gene will develop hemophilia. Males have one X chromosome and one Y chromosome. If they acquire a defective X chromosome, they will surely have hemophilia for they only have a single X chromosome (Yhe, 1997, 229). Proposition 7: Females who inherit the defective gene will become carriers who may, in turn, have a 50 percent chance of passing it on to their children. Dissertation? Females have two X chromosomes. If they acquire a defective X chromosome, they will still not have the disease for they have another X chromosome that will prevent them from having the disease. Thus, there will only be a probability that they will pass this defective gene on back, to her male offspring (Yhe, 1997, 229). Proposition 8: The ability to stem blood loss after vascular injury is vital for all vertebrate species. Blood clotting is very important to all vertebrate species for it stops the dissertation poster examples blood from coming out of our body.

If will not be able to clot blood, it will continuously bleed out until we run out of it and Essay Mountain die (Ratnoff, 1997, 7). Proposition 9: When bleeding occurs in a closed space such as the dissertation poster examples tip of Essay, a finger or toe, blood loss is less. This is dissertation poster, such because of the back-pressure of be a good cashier, extravastated blood which pushes the blood back at the same time while it is bleeding out (Ratnoff, 1997, 7). Proposition 10: Extravascular pressure may also be important in limiting bleeding with joint spaces. In the special case of the uterus, bleeding after delivery is examples, further controlled by contraction of the myometrium, applying external pressure on blood vessels at the site of the avulsed placenta.

A similar mechanism may participate in the control of menstrual bleeding (Ratnoff, 1997, 7). Proposition 11: The hemostatic system, consisting of the blood vessels and examples of factors of production the blood, plays a crucial role in human survival. Blood is a body fluid that delivers essential substances like nutrients and oxygen to the cells of the body. Dissertation? Blood also transports carbon dioxide and other waste products away from the cells, to the lungs, kidneys, and digestive system; from there they are removed from the body. Essay Cold? Our body has billions of cells that need regular supply of fuel and oxygen to function. Blood meets these requirements and ensures proper functioning of cells, thus, also making sure that our body keeps in dissertation poster, good health (Berntorp, 1997, 181). Proposition 12: Factor IX deficiency is 4-6 times less prevalent than factor VIII deficiency. 1 in 5,000 males worldwide are born with hemophilia A, while 1 in 30,000 males worldwide are born with hemophilia B (Lusher, 1997, 203). Proposition 13: Hemophilia carrier assessment can be made in freak the mighty review, several ways.

There are number of poster examples, ways in order to know or evaluate whether someone is a possible carrier of hemophilia or not. The Three Essay? One is based upon the detailed family tree where no uncertainties are present (Goodeve, 1997, 63). Proposition 14: The starting point for any family study in hemophilia must be and accurate family tree. An accurate family tree is needed in showing the precise relationship between affected and non-affected family members. The nature of the inherited condition must be certain and ethnic background of the family may also be important (Goodeve, 1997, 64). Proposition 15: Hemophilia may cause deep muscle bleeding that leads to swelling of a limb.

The swelling may press on nerves and lead to numbness or pain. This may result in a reluctance to use that limb (Rickard, 1997, 53). Proposition 16: Patients with hemophilia who undergo liver transplantation are cured of dissertation, their hemophilia. This is because factor VIII and factor IX are synthesized in the liver. FIX is produced by hepatocytes. The exact site of looking back, synthesis of FVIII in the liver is unknown (Rickard, 1997, 53). Proposition 17: Patients with hemophilia should not be deprived of engaging in examples, sports. Those with hemophilia are still recommended to freak review, engage in dissertation examples, sports and over my life various physical activities in dissertation poster, order to have a healthy lifestyle, however, they are advised to avoid sports that may cause them to what between points and germany’s surrender?, bleed (Rickard, 1997, 55). Proposition 18: People with hemophilia are at greater risks of dissertation poster, receiving contaminated blood products. Until the mid-1980s, it was more likely for people with hemophilia to become infected with the human immunodeficiency virus (HIV) or hepatitis through contaminated blood products (Rickard, 1997, 56).

Proposition 19: People with or without hemophilia just have the same life expectancy. Hemophilia doesnt affect ones life span as long as it is freak review, diagnosed and examples treated as early as possible. Ones lifespan depends on his lifestyle and way of living (Rickard, 1997, 58). The proponent tried to compare and contrast the differences and similarities of the two major types of hemophilia. The proponent concludes that there is really no permanent treatment to hemophilia; however, patients undergoing liver transplant are cured of their disease. Of Production? Hemophilic patients life expectancy is just the same as those people without hemophilia as long as its given proper treatment every time. Dissertation Poster Examples? Hemophilic patients should not be deprived of the mighty review, being engaged in sports, but are recommended take sports with less physical contact and refrain from bleeding.

There are certain facts that the two types of hemophilia are different in some of its aspects. First, the reason why patients with hemophilia A and hemophilia B bleeds is because they lack protein factors in their blood. The former lacks in dissertation poster examples, factor VIII while the of factors latter lacks in factor IX. Second, factor IX deficiency is 4-6 times less prevalent than factor VIII deficiency for there is only 1 person with hemophilia A in every 5,000 males; on the other hand, there is 1 person with hemophilia B in every 30,000 males. However, the two main types of the dissertation examples disease also have their similarities as it is almost clinically identical in nature. Both types of hemophilia only affect men because this is The Three Empires Essay, a sex-linked disease and is found in examples, the X chromosome. And men have an XY chromosome, so if they acquired a defected X chromosome, they will surely acquire the disease. Unlike on the case of the what between president wilson’s points and germany’s women, they have an XX chromosome, so if they acquired a defected X chromosome, they still have another X chromosome which can protect them from having the disease. This disease affects all people of all races and dissertation poster examples ethnics globally. For further study, I recommend the readers to fourteen surrender?, continually research for the disease hemophilia specifically their treatment and diagnoses. At the present time with the given present level of technology, there is still no permanent treatment for this disease.

What we have are just merely remedies which cures the disease only for a certain period of time but it doesnt really cure it permanently. Howard, M. (2002). Hematology. United Kingdom: Harcourt Press. Waterbury, L. (1996). Dissertation Examples? Hematology.

USA: Vicks. Forbes, C.D. Examples Of Production? (1997). HEMOPHILIA. UK: Alden Press Ltd. Aledort, L. (1997). Poster? HEMOPHILIA. London: Chapman Hall. Li, S. (2008). Electroporation Protocols Preclinical and Clinical Medicine.

Totowa, New Jersey: Humana Press. Tefferi, A. (2001). Primary Hematology. Totowa, New Jersey: Humana Press. Is this the perfect essay for you? Save time and order Research on Hemophilia. essay editing for only $13.9 per examples of factors of production page. Top grades and quality guaranteed! Relevant essay suggestions for Research on Hemophilia. 1. Why will you want to dissertation, monitor his fluid status very carefully?

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A Framework for dissertation Software Product Line Practice, Version 5.0. The hardest single part of building a software system is deciding precisely what to build. No other part of the conceptual work is as difficult as establishing the detailed technical requirements . . . No other part of the work so cripples the resulting system if done wrong. No other part is Essay on, as difficult to rectify later [Brooks 1987a]. So wrote Fred Brooks in 1987, and so it remains today [Davis 1990a, Faulk 1997a]. The inability to produce complete, correct, and unambiguous software requirements is still considered the major cause of software failure today [Dorfman 1997a].

Requirements are statements of what the system must do, how it must behave, the properties it must exhibit, the qualities it must possess, and the constraints that the system and its development must satisfy. The Institute of Electrical and Electronics Engineers (IEEE) defines a requirement as. a condition or capability needed by a user to solve a problem or achieve an dissertation examples, objective a condition or capability that must be met or possessed by a system or system component to satisfy a contract, standard, specification, or other formally imposed document a documented representation of a condition or capability as in be a cashier, definition 1 or 2 [IEEE 1990a] Requirements engineering emphasizes the use of systematic and repeatable techniques that ensure the completeness, consistency, and dissertation relevance of the system requirements [Sommerville 1997a]. Specifically, requirements engineering encompasses requirements elicitation, analysis, specification, verification, and management, where. Requirements elicitation is the process of discovering, reviewing, documenting, and understanding the user's needs and constraints for the system. Requirements analysis is the process of refining the user's needs and constraints. Requirements specification is the process of documenting the user's needs and constraints clearly and precisely. Requirements verification is the process of ensuring that the system requirements are complete, correct, consistent, and clear. Requirements management is the process of the mighty, scheduling, coordinating, and documenting the requirements engineering activities (that is, elicitation, analysis, specification, and verification) [Dorfman 1997a].

Requirements engineering is complex because of the three roles involved in producing even a single requirement: the requestor (referred to as the user in examples, the IEEE definition), the developer (who will design and Essay on Cold implement the poster examples system), and the author (who will document the how to cashier requirements). Dissertation Poster Examples! Typically, the requestor understands the problem to be solved by the system but not how to develop a system. The developer understands the tools and techniques required to looking over, construct and maintain a system but not the problem to be solved by that system. The author needs to create a statement that communicates unambiguously to the developer what the requestor desires. Hence, requirements address a fundamental communications problem. The communications problem is further compounded by the number and dissertation examples diversity of system requestors.

In practice, any system stakeholder has needs and expectations (that is, requirements) for the system. The role of system stakeholder is played by any of the various people or systems involved in or affected by a system's development. This group includes executives (who know the organization's business goals and constraints), end users (who know how the products will be used), marketers (who know the market demands), technical managers (who know the available personnel), and developers (who know the available tools and technology). Examples Of Factors! It can potentially include legal experts, government agencies, and insurance experts. Successful requirements engineering depends on examples the identification and solicitation of the appropriate community of stakeholders. Reconciling the looking diverse needs and expectations of the dissertation examples various system stakeholders necessitates tradeoffs#150;that is, decisions between potentially conflicting requirements from different stakeholders.

Tradeoffs require mechanisms for capturing and analyzing the Mountain different stakeholder requirements, for recognizing the conflicting requirements of different stakeholders, for deciding among those conflicting requirements, and for recording the results of those decisions. Dissertation Poster! Tradeoffs are captured as system decisions that are linked to the affected requirements. Requirements are pervasive, continuously affecting all development and maintenance phases of what was the between and germany’s, a system's development by providing the primary information needed during them. The requirements form a trigger mechanism for the development and maintenance efforts. Testing, for poster examples instance, depends on a precise statement of quality and behavioral requirements to define the standard of correctness against which to test. The longer the system's lifetime, the more it is exposed to changes in the requirements that result from changes in the needs and the mighty review concerns of its stakeholders.

For example, the end user's demands can change as a result of new features offered by poster, a competing organization's products. The organization's business goals and constraints can change as a result of market demands, new laws, or new insurance regulations. New technologies and software tools such as operating systems can change the way the system is freak review, constructed. Such changes require mechanisms for managing them#150;that is, a requirements-change-management process. That process is based on the traceability links between the requirements and the system work products and between the requirements and the related decisions and tradeoffs. Dissertation Examples! The following sections describe requirements engineering for products: Core Asset Development describes other kinds of requirements that also need to be managed for a software product line, such as the production constraints. Aspects Peculiar to Product Lines. Product line requirements constitute an important and tangible core asset.

They define the examples of factors of production products in the product line together with the features of and the constraints on those products. These requirements are tightly coupled with the dissertation product line's scope definition and evolve together [Clements 2002c, p. 180]. Cold! Requirements common across the product line are written with variation points that can be filled in or exercised to create product-specific requirements. These variation points may be small, such as replacing a symbolic name such as max_nbr_of_users with a value such as 150, or may be substantial, such as leaving a placeholder for an entire specification of part of the behavior. Sometimes the variation point will map to null for a product, corresponding to poster examples, a feature that the product does not have. And there must be some mechanism by which the complete set of requirements for The Three Essay a particular product (common plus unique) can be produced quickly and easily, implying that the product-specific requirements are stored as a set of deltas relative to examples, the product-line-wide requirements specification. Requirements engineering for a product line differs from requirements engineering for between president wilson’s points and germany’s surrender? single systems as follows: Requirements elicitation for a product line must capture anticipated variations explicitly over the foreseeable lifetime of the product line.

This means that the community of examples, stakeholders is probably larger than for single-system requirements elicitation and may well include domain experts, market experts, and back others. Requirements elicitation focuses on the scope, explicitly capturing the anticipated variation by the application of domain analysis techniques, the incorporation of existing domain analysis models, and the incorporation of use cases that capture the variations that are expected to occur over the lifetime of the examples product line (e.g., change cases [Ecklund 1996a] and use case variation points [Jacobson 1997a]). Requirements analysis for a product line involves finding commonalities and identifying variations. It may also involve a more vigorous feedback mechanism to the requestors, pointing out where a particular system might achieve economies if it could use more common requirements. And requirements analysis has the product line scope as one of its inputs#150;an artifact that does not exist outside the product line context.

Requirements analysis includes a commonality and variability analysis (a technique used frequently in domain analysis) on the elicited product line requirements to identify the opportunities for large-grained reuse within the examples of factors product line. Dissertation Examples! Two such techniques are feature-oriented domain analysis (FODA) [Kang 1990a] and use cases [Jacobson 1997a]. Requirements specification now includes documentation of a product-line-wide set of requirements and product-specific requirements. The product-line-wide requirements include symbolic placeholders that the various product-specific requirements documents fill in, expand, or instantiate. Requirements verification now includes a broader reviewer pool and what was the connection between fourteen points occurs in stages. First, the common product line requirements must be verified. Later, as each product comes on the scene (or is updated), its product-specific requirements must be verified. But the examples product-line-wide requirements must also be verified to was the connection fourteen surrender?, make sure that they make sense for dissertation examples this product. Requirements management must now make allowances for the dual nature of the requirements engineering process and the staged (common, specific) nature of the looking back over activity. Change-management policies must provide a formal mechanism for proposing changes in the product line and dissertation examples supporting the systematic assessment of The Three, how the proposed changes will impact the product line.

Change-management policies govern how changes in dissertation poster examples, the product line requirements are proposed, analyzed, and reviewed. The coupling between the product line requirements and the core assets is leveraged by the use of traceability links between those requirements and their associated core assets. Changes in the requirements can then trigger the appropriate changes in the related core assets [Sommerville 1997a]. The Configuration Management practice area describes change management in more detail. Application to Core Asset Development. Examples Of Factors Of Production! First of all, the requirements artifacts produced by requirements engineering are important core assets in dissertation examples, their own right. Beyond that, requirements engineering creates the product line requirements that feed the development and acquisition of other core assets. The requirements artifacts will help to.

determine the feasibility and refine the scope and business case of a product line. The initial version of the business case is frequently based on on Cold Mountain an informal notion of the scope. Requirements engineering refines the dissertation poster examples scope, and hence the business case, by determining more precisely the requirements for the product line. That more precise definition of the how to be a good cashier product line provides input to the business case activity for a correspondingly more precise determination of that product line's feasibility. lay the poster groundwork for the product line architecture, which must accommodate the commonalities and variabilities identified in The Three Essay, the requirements ensure that the other core assets support the anticipated variations determine the schedules and budgets for dissertation examples the product line and its products create the test cases and other test artifacts for what president points and germany’s products in the product line. A significant difference in dissertation, requirements engineering for product lines involves a rapid, initial pass through the requirements for Essay on Cold key stakeholders to initiate early design work, capturing the high-level requirements that affect the poster examples initial design (that is, the architecturally significant requirements [Jacobson 1997a]). The purpose of this pass is to compress the time to initial delivery and to demonstrate the feasibility of and establish the credibility of the product line approach#150;in short, to provide an Essay, early justification of the investment [Graham 1998a]. Although this early justification is desirable in poster, single-product development, it is more critical for a software product line.

Application to Product Development. Requirements engineering plays a key role in. determining the feasibility of producing a particular product as part of the product line. You can use a statement of the requirements specific to that candidate product to help estimate the what was the between president wilson’s points surrender? cost of developing the product. the production, testing, and deployment of the particular product. Requirements play a role in these activities just as they do for single-system development. the evolution of the product line (that is, the incorporation of changes) that results from examples that product development. Product-specific requirements often grow up to become product line requirements if they can be slightly generalized or if they pop up in more than one product. Essay Cold! That is the primary mechanism for the evolution of software product lines over time. Examples! To expand on the first point, determining the Cold Mountain feasibility of an additional product in a product line is an ongoing activity that is part of building the business case for that product. The initial version of that business case is frequently based on an informal description of the prospective product. Requirements engineering activities#150;particularly elicitation and analysis#150;support the business case for the product by determining more precisely the requirements for that product.

The product line requirements guide the dissertation examples elicitation of the specific requirements for that product. Requirements analysis determines the variance between the product line and the product-specific requirements. That variance provides input to the business case activity for a correspondingly more precise cost estimate for building the specific product as part of the product line (that is, determination of that product's feasibility). Domain analysis techniques: These techniques can be used to expand the scope of the requirements elicitation, to identify and plan for anticipated changes, to determine fundamental commonalities and variations in the products of the product line, and to support the creation of robust architectures. (See the Understanding Relevant Domains practice area.) One of these techniques, FODA, has been incorporated recently in a newer approach to requirements engineering for product lines. Product Line Analysis (PLA) combines traditional object-based analysis with FODA feature modeling and stakeholder-view modeling to elicit, analyze, specify, and verify the requirements for a product line. Feature modeling facilitates the identification and analysis of the product line's commonality and variability and provides a natural vehicle for requirements specification. Stakeholder-view modeling supports the The Three completeness of the requirements elicitation, while the PLA work products (the object model, use case model, feature model, and product line terminology dictionary) provide incremental verification of the requirements modeling [SEI 2007d, Chastek 2001a].

Stakeholder-view modeling: This technique can be used to support the prioritized modeling of the significant stakeholder requirements for the product line. Dissertation! Viewpoint modeling is based on the recognition that a system must satisfy the needs and how to be a good cashier expectations of the many system stakeholders, who all have their own perspectives (views) of the system. Dissertation Poster! Each stakeholder view can be modeled separately as a set of system requirements. These models are core assets that support the was the wilson’s fourteen surrender? explicit identification of conflicts and determination of tradeoffs, among the examples needs of the of factors of production system stakeholders [Sommerville 1997a]. Poster! Feature modeling: This technique can be used to complement object and use case modeling and to organize the results of the commonality and variability analysis in preparation for reuse. Connection Between President Wilson’s Fourteen And Germany’s Surrender?! Features are user-visible aspects or characteristics of a system that are organized into a tree of And/Or nodes to poster, identify the commonalities and variabilities within the system. Feature modeling is an integral part of the FODA method [Kang 1990a] and good cashier the feature-oriented reuse method (FORM) [Kang 1998a]. In the latter, the requirements for a family of related systems are organized according to that family's features. The commonalities and variabilities within those features are then exploited to create a set of reference models (that is, software architectures and poster examples components) that can be used to implement the examples of factors products of that family. Feature modeling has also been integrated into the reuse-driven software engineering business (RSEB) [Jacobson 1997a, Griss 1998a].

Use case modeling: This technique can be used with variation points to capture and describe commonality and variability within product line requirements. A variation point is a location within a use case where a variation (that is, variability) occurs. That variation is captured in a variant that describes the context and mode of the variation. The mechanisms supported for capturing and describing different types of variation within use cases include inheritance, uses, extensions, extension points, and parameterization [Jacobson 1997a]. Change-case modeling: This technique can be used to explicitly identify and capture anticipated changes in poster, a system and to ultimately incorporate them explicitly in the design to enhance its long-term robustness.

Change cases are use cases that describe potential future requirements for a system. They are linked to the existing system use cases that will be affected if and freak when the future requirements are adopted. The inclusion of dissertation poster examples, change cases allows the designers to plan for and more effectively accommodate anticipated changes [Ecklund 1996a]. Traceability of requirements to their associated work products: This technique can be used to ensure that the design and implementation of a system satisfy the requirements for that system. Requirements traceability links the requirements backward to their sources (a stakeholder, for example) and forward to the resulting system development work products (a component, for example). In addition to assisting with the elicitation and verification of requirements, requirements traceability is critical in Essay on Cold, determining the potential impact of proposed changes in poster examples, a system [Ramesh 1997a, Sommerville 1997a]. The major risk associated with requirements engineering is failure to capture the right requirements over the life of the looking back over product line. Documenting the wrong or inappropriate requirements, failing to keep the requirements up-to-date, or failing to document the requirements at all puts the architect and examples the component developers at good cashier a grave disadvantage. They will be unable to produce systems that satisfy the customers and fulfill the market expectations. Inappropriate requirements can result from the following: failure to distinguish between product-line-wide requirements and dissertation poster product-specific requirements: These different kinds of on Cold Mountain, requirements have different audiences in a product line. Dissertation Examples! The core asset builders need to know the requirements they must build to, while the product-specific software builders must know what is expected of them. insufficient generality: Insufficient generality in the requirements leads to a design that is too brittle to deal with the change actually experienced over the lifetime of the product line. excessive generality: Overly general requirements lead to excessive effort in producing both core assets (to provide that generality) and specific products (which must turn that generality into examples, a specific instantiation). wrong variation points: Incorrect determination of the variation points results in dissertation, inflexible products and the inability to respond rapidly to customer needs and over my life market shifts. failure to account for examples qualities other than behavior: Product line requirements (and software requirements in general) should capture requirements for quality attributes such as performance, reliability, and security.

In addition, requirements engineering for a product line is subject to the risks enumerated in the Understanding Relevant Domains practice area. This Fraunhofer Institute report is based on the findings of the Gesellschaft fur Informattik (GI) Working Group, which includes organizations such as Hewlett-Packard, Bosch, RWTH Aachen, and back sdm. Dissertation Poster! Birk and colleagues provide a good description of the problems associated with requirements engineering for software product lines from the industry point of view. These are two good textbooks for requirements engineering. Of particular value in Somerville and Sawyer's book is a table that describes the basic, intermediate, and advanced requirements engineering guidelines. Essay! This is a tutorial in examples, book form that is based on the most significant requirements engineering papers of the last two decades. Examples Of Factors Of Production! Faulk provides an excellent, brief introduction to dissertation poster examples, requirements engineering, describing such techniques as functional decomposition, structured analysis, operational specification, and object-oriented analysis. A continuing problem with the adoption of software product lines has been the lack of effective tool support for product line requirements engineering. This report describes the how to Requirements Management for Product Lines (REMAP) software tool.

REMAP is a prototype that operates on top of dissertation examples, existing requirements engineering tools, such as DOORS, and provides the additional product line support lacking in those existing commercial tools. The earlier work of Schmid and on Mountain colleagues provides a more complete description of REMAP [Schmid 2005a].

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when I describe my life in Sudan. Connection Between? In additions, I use form /rhyme, language and imagery to express my sentiments. Analyzing my poem- . Dissertation Examples? Stanzas- This poem has 4 stanzas. I chose to use stanzas to break the poem into sections about each of my 4 memorable moments while living in Africa. All stanzas have the same amount of line because it made the poem easier to read and it gave it a sense of connection wilson’s points surrender?, completeness about all of my memories form Africa. Aside from giving attentions to the poems stanzas.

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